Rizaldy Taslim Pinzon (2024) SEVERE SUBCONJUNCTIVAL BLEEDING IN A PATIENT WITH CONCOMITANT USE OF WARFARIN AND VALPROIC ACID. Acta Medica Bulgarica Journal, 51 (S1). pp. 5-7. ISSN 0324-1750
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Abstract
Drug interactions with vitamin K antagonist may involve antiepileptic drug. Numerous antiepileptic drugs are strong inducers or inhibitors of liver enzymes and affect warfarin metabolism, including valproic acid, which is capable of displacing warfarin from the protein binding site. Although this type of drug interaction is less widely recognized, it is a phenomenon that causes significant changes in the INR. We report a case of severe subconjunctival bleeding in patient with concomitant use of warfarin and valproic acid. The management include cessation of the drug, conservative eye treatment, and vitamin K. The case was fully resolved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | warfarin, divalproex acid, subconjunctival bleeding, stroke |
| Subjects: | R Kedokteran. Medis > Kedokteran (Umum) R Kedokteran. Medis > Farmasi dan Bahan Medis (materia medica) |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | Beatrix Stefany |
| Date Deposited: | 26 Sep 2024 03:16 |
| Last Modified: | 26 Sep 2024 03:16 |
| URI: | http://katalog.ukdw.ac.id/id/eprint/9452 |
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