THE ROLE OF HOMOCYSTEINE LEVELS AS A RISK FACTOR OF ISCHEMIC STROKE EVENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Rizaldy Taslim Pinzon (2023) THE ROLE OF HOMOCYSTEINE LEVELS AS A RISK FACTOR OF ISCHEMIC STROKE EVENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Frontiers in Neurology, 10. pp. 1-10. ISSN 1664-2295

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Official URL: https://doi.org/10.3389/fneur.2023.1144584

Abstract

Introduction: Among numerous risk factors, homocysteine (Hcy) has been linked to cerebral infarction; however, results have been inconsistent. This review aimed to conduct a meta-analysis of published studies to investigate the relationship between plasma Hcy levels and the risk of ischemic stroke. Methods: A systematic literature search was conducted until November 2022 to obtain articles reporting Hcy levels in ischemic stroke patients. Review Manager software was used to perform all statistical analyses (version 5.3). Results: Initial investigation yielded 283 articles. The final evaluation included 21 articles, including two prospective studies, one retrospective cohort, and 18 case-control studies. These studies included 9888 participants, of which 5031 were admitted patients with ischemic stroke. An integrated analysis revealed that ischemic stroke patients had significantly higher levels of Hcy than controls (mean difference (MD) = +3.70, 95% confidence interval (CI) = 2.42-5.81, p < 0.001). Conclusion: This meta-analysis and systematic review indicate that ischemic stroke patients have significantly higher homocysteine levels than controls. Detecting hyperhomocysteinemia and reducing homocysteine levels should be explored among individuals at increased risk for ischemic stroke.

Item Type:	Article
Uncontrolled Keywords:	homocysteine, ischemic stroke, risk factor, systematic review, meta-analysis
Subjects:	R Kedokteran. Medis > RC Kedokteran Internal > RC0321 Ilmu Syaraf. Psikiatri Biologis. Psikiatri Syaraf
Divisions:	Fakultas Kedokteran
Depositing User:	Beatrix Stefany
Date Deposited:	12 Sep 2024 05:16
Last Modified:	12 Sep 2024 05:16
URI:	http://katalog.ukdw.ac.id/id/eprint/9143

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