LEUKOCYTE COUNT AND NEUTROPHIL-TO-LYMPHOCYTE RATIO AS SIMPLE HEMATOLOGIC PREDICTORS OF STROKE SEVERITY AND FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS

Rizaldy Taslim Pinzoo and Vanessa Veronica (2022) LEUKOCYTE COUNT AND NEUTROPHIL-TO-LYMPHOCYTE RATIO AS SIMPLE HEMATOLOGIC PREDICTORS OF STROKE SEVERITY AND FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS. Open Neurology Journal, 16. pp. 1-7. ISSN 1874-205X

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Official URL: http://dx.doi.org/10.2174/1874205X-v16-e2209280

Abstract

Background: It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain. Objective: This clinical study aimed to evaluate the association of leukocyte count and neutrophil-to-lymphocyte ratio with stroke severity and functional outcome in acute ischemic stroke patients. Methods: This hospital-based, retrospective observational study included 112 subjects with acute ischemic stroke. All subjects had their demographic, clinical, and laboratory data obtained. The leukocyte count and neutrophil-to-lymphocyte ratio were evaluated by stroke severity on admission and 3-month functional outcome. The severity of stroke at admission was measured using the National Institutes of Health Stroke Scale (NIHSS), whereas the Barthel Index was used to measure 3-month functional outcome (BI). We conducted a regression analysis, adjusting for any confounding variables. Results: Higher leukocyte count was significantly associated with increased risk of stroke severity (odds ratio [OR] 1.391, 95% confidence intervals [CI], 1.121-1.725, p: 0.003) and unfavorable functional outcome (OR 1.434, 95% CI, 1.068-1.925, p: 0.017). Higher neutrophil-to-lymphocyte ratio was not significantly associated with increased risk of stroke severity (OR 1.181, 95% CI, 0.947-1.474, p: 0.140) and unfavorable functional outcome (OR 1.246, 95% CI, 0.905-1.716, p: 0.177). Conclusion: Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome

Item Type:	Article
Uncontrolled Keywords:	Ischemic stroke, Inflammation, Leukocyte count, Neutrophil-to-lymphocyte ratio, Prognosis, Stroke
Subjects:	R Kedokteran. Medis > Kedokteran Internal
Divisions:	Fakultas Kedokteran
Depositing User:	Beatrix Stefany
Date Deposited:	20 Sep 2024 01:51
Last Modified:	20 Sep 2024 01:51
URI:	http://katalog.ukdw.ac.id/id/eprint/9319

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