eprintid: 9452
rev_number: 8
eprint_status: archive
userid: 2098
dir: disk0/00/00/94/52
datestamp: 2024-09-26 03:16:00
lastmod: 2024-09-26 03:16:00
status_changed: 2024-09-26 03:16:00
type: article
metadata_visibility: show
contact_email: repository@staff.ukdw.ac.id
creators_name: , Rizaldy Taslim Pinzon
creators_id: 0517057601
title: SEVERE SUBCONJUNCTIVAL BLEEDING IN A PATIENT WITH CONCOMITANT USE OF WARFARIN AND VALPROIC ACID
ispublished: pub
subjects: R1
subjects: RS
divisions: fak_kedokteran
full_text_status: public
keywords: warfarin, divalproex acid, subconjunctival bleeding, stroke
abstract: Drug interactions with vitamin K antagonist may involve antiepileptic drug. Numerous antiepileptic drugs are strong inducers or inhibitors of liver enzymes and affect warfarin metabolism, including valproic acid, which is capable of displacing warfarin from the protein binding site. Although this type of drug interaction is less widely recognized, it is a phenomenon that causes significant changes in the INR. We report a case of severe subconjunctival bleeding in patient with concomitant use of warfarin and valproic acid. The management include cessation of the drug, conservative eye treatment, and vitamin K. The case was fully resolved.
date: 2024-06-28
publication: Acta Medica Bulgarica Journal
volume: 51
number: S1
publisher: Walter de Gruyter GmbH
pagerange: 5-7
id_number: doi:10.2478/AMB-2024-0024
refereed: TRUE
issn: 0324-1750
official_url: https://doi.org/10.2478/AMB-2024-0024
funders: drpinzon17@gmail.com
citation:   Rizaldy Taslim Pinzon  (2024) SEVERE SUBCONJUNCTIVAL BLEEDING IN A PATIENT WITH CONCOMITANT USE OF WARFARIN AND VALPROIC ACID.  Acta Medica Bulgarica Journal, 51 (S1).  pp. 5-7.  ISSN 0324-1750     
document_url: https://katalog.ukdw.ac.id/9452/1/SEVERE%20SUBCONJUNCTIVAL%20BLEEDING%20IN%20A%20PATIENT%20WITH....pdf