TY  - JOUR
PB  - Walter de Gruyter GmbH
A1  - Rizaldy Taslim Pinzon
EP  - 7
N2  - Drug interactions with vitamin K antagonist may involve antiepileptic drug. Numerous antiepileptic drugs are strong inducers or inhibitors of liver enzymes and affect warfarin metabolism, including valproic acid, which is capable of displacing warfarin from the protein binding site. Although this type of drug interaction is less widely recognized, it is a phenomenon that causes significant changes in the INR. We report a case of severe subconjunctival bleeding in patient with concomitant use of warfarin and valproic acid. The management include cessation of the drug, conservative eye treatment, and vitamin K. The case was fully resolved.
AV  - public
VL  - 51
SP  - 5
KW  - warfarin
KW  -  divalproex acid
KW  -  subconjunctival bleeding
KW  -  stroke
JF  - Acta Medica Bulgarica Journal
UR  - https://doi.org/10.2478/AMB-2024-0024
SN  - 0324-1750
Y1  - 2024/06/28/
ID  - katalog9452
IS  - S1
TI  - SEVERE SUBCONJUNCTIVAL BLEEDING IN A PATIENT WITH CONCOMITANT USE OF WARFARIN AND VALPROIC ACID
ER  -