eprintid: 9319
rev_number: 9
eprint_status: archive
userid: 2098
dir: disk0/00/00/93/19
datestamp: 2024-09-20 01:51:33
lastmod: 2024-09-20 01:51:33
status_changed: 2024-09-20 01:51:33
type: article
metadata_visibility: show
contact_email: repository@staff.ukdw.ac.id
creators_name: , Rizaldy Taslim Pinzoo
creators_name: , Vanessa Veronica
title: LEUKOCYTE COUNT AND NEUTROPHIL-TO-LYMPHOCYTE RATIO AS SIMPLE HEMATOLOGIC PREDICTORS OF STROKE SEVERITY AND FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS
ispublished: pub
subjects: RC
divisions: fak_kedokteran
full_text_status: public
keywords: Ischemic stroke, Inflammation, Leukocyte count, Neutrophil-to-lymphocyte ratio, Prognosis, Stroke
abstract: Background:
It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and
neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain.
Objective:
This clinical study aimed to evaluate the association of leukocyte count and neutrophil-to-lymphocyte ratio with stroke severity and functional
outcome in acute ischemic stroke patients.
Methods:
This hospital-based, retrospective observational study included 112 subjects with acute ischemic stroke. All subjects had their demographic,
clinical, and laboratory data obtained. The leukocyte count and neutrophil-to-lymphocyte ratio were evaluated by stroke severity on admission and
3-month functional outcome. The severity of stroke at admission was measured using the National Institutes of Health Stroke Scale (NIHSS),
whereas the Barthel Index was used to measure 3-month functional outcome (BI). We conducted a regression analysis, adjusting for any
confounding variables.
Results:
Higher leukocyte count was significantly associated with increased risk of stroke severity (odds ratio [OR] 1.391, 95% confidence intervals [CI],
1.121-1.725, p: 0.003) and unfavorable functional outcome (OR 1.434, 95% CI, 1.068-1.925, p: 0.017). Higher neutrophil-to-lymphocyte ratio was
not significantly associated with increased risk of stroke severity (OR 1.181, 95% CI, 0.947-1.474, p: 0.140) and unfavorable functional outcome
(OR 1.246, 95% CI, 0.905-1.716, p: 0.177).
Conclusion:
Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome
date: 2022-11-23
publication: Open Neurology Journal
volume: 16
publisher: Bentham Science Publishers B.V.
pagerange: 1-7
id_number: doi:10.2174/1874205X-v16-e2209280
refereed: TRUE
issn: 1874-205X
official_url: http://dx.doi.org/10.2174/1874205X-v16-e2209280
citation:   Rizaldy Taslim Pinzoo and Vanessa Veronica  (2022) LEUKOCYTE COUNT AND NEUTROPHIL-TO-LYMPHOCYTE RATIO AS SIMPLE HEMATOLOGIC PREDICTORS OF STROKE SEVERITY AND FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS.  Open Neurology Journal, 16.  pp. 1-7.  ISSN 1874-205X     
document_url: https://katalog.ukdw.ac.id/9319/1/Leukocyte%20Count%20and%20Neutrophil-To-Lymphocyte%20Ratio.pdf