TY  - JOUR
JF  - Open Neurology Journal
PB  - Bentham Science Publishers B.V.
AV  - public
VL  - 16
SP  - 1
KW  - Ischemic stroke
KW  -  Inflammation
KW  -  Leukocyte count
KW  -  Neutrophil-to-lymphocyte ratio
KW  -  Prognosis
KW  -  Stroke
A1  - Rizaldy Taslim Pinzoo
A1  - Vanessa Veronica
ID  - katalog9319
Y1  - 2022/11/23/
SN  - 1874-205X
N2  - Background:
It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and
neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain.
Objective:
This clinical study aimed to evaluate the association of leukocyte count and neutrophil-to-lymphocyte ratio with stroke severity and functional
outcome in acute ischemic stroke patients.
Methods:
This hospital-based, retrospective observational study included 112 subjects with acute ischemic stroke. All subjects had their demographic,
clinical, and laboratory data obtained. The leukocyte count and neutrophil-to-lymphocyte ratio were evaluated by stroke severity on admission and
3-month functional outcome. The severity of stroke at admission was measured using the National Institutes of Health Stroke Scale (NIHSS),
whereas the Barthel Index was used to measure 3-month functional outcome (BI). We conducted a regression analysis, adjusting for any
confounding variables.
Results:
Higher leukocyte count was significantly associated with increased risk of stroke severity (odds ratio [OR] 1.391, 95% confidence intervals [CI],
1.121-1.725, p: 0.003) and unfavorable functional outcome (OR 1.434, 95% CI, 1.068-1.925, p: 0.017). Higher neutrophil-to-lymphocyte ratio was
not significantly associated with increased risk of stroke severity (OR 1.181, 95% CI, 0.947-1.474, p: 0.140) and unfavorable functional outcome
(OR 1.246, 95% CI, 0.905-1.716, p: 0.177).
Conclusion:
Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome
TI  - LEUKOCYTE COUNT AND NEUTROPHIL-TO-LYMPHOCYTE RATIO AS SIMPLE HEMATOLOGIC PREDICTORS OF STROKE SEVERITY AND FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS
EP  - 7
UR  - http://dx.doi.org/10.2174/1874205X-v16-e2209280
ER  -