%0 Journal Article
%@ 1874-205X
%A Rizaldy Taslim Pinzoo
%A Vanessa Veronica
%D 2022
%F katalog:9319
%I Bentham Science Publishers B.V.
%J Open Neurology Journal
%K Ischemic stroke, Inflammation, Leukocyte count, Neutrophil-to-lymphocyte ratio, Prognosis, Stroke
%P 1-7
%T LEUKOCYTE COUNT AND NEUTROPHIL-TO-LYMPHOCYTE RATIO AS SIMPLE HEMATOLOGIC PREDICTORS OF STROKE SEVERITY AND FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS
%U https://katalog.ukdw.ac.id/9319/
%V 16
%X Background:  It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and  neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain.  Objective:  This clinical study aimed to evaluate the association of leukocyte count and neutrophil-to-lymphocyte ratio with stroke severity and functional  outcome in acute ischemic stroke patients.  Methods:  This hospital-based, retrospective observational study included 112 subjects with acute ischemic stroke. All subjects had their demographic,  clinical, and laboratory data obtained. The leukocyte count and neutrophil-to-lymphocyte ratio were evaluated by stroke severity on admission and  3-month functional outcome. The severity of stroke at admission was measured using the National Institutes of Health Stroke Scale (NIHSS),  whereas the Barthel Index was used to measure 3-month functional outcome (BI). We conducted a regression analysis, adjusting for any  confounding variables.  Results:  Higher leukocyte count was significantly associated with increased risk of stroke severity (odds ratio [OR] 1.391, 95% confidence intervals [CI],  1.121-1.725, p: 0.003) and unfavorable functional outcome (OR 1.434, 95% CI, 1.068-1.925, p: 0.017). Higher neutrophil-to-lymphocyte ratio was  not significantly associated with increased risk of stroke severity (OR 1.181, 95% CI, 0.947-1.474, p: 0.140) and unfavorable functional outcome  (OR 1.246, 95% CI, 0.905-1.716, p: 0.177).  Conclusion:  Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome