@article{katalog9319,
           month = {November},
          volume = {16},
          author = {Rizaldy Taslim Pinzoo and Vanessa Veronica},
         journal = {Open Neurology Journal},
       publisher = {Bentham Science Publishers B.V.},
           title = {LEUKOCYTE COUNT AND NEUTROPHIL-TO-LYMPHOCYTE RATIO AS SIMPLE HEMATOLOGIC PREDICTORS OF STROKE SEVERITY AND FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS},
            year = {2022},
           pages = {1--7},
        abstract = {Background:
It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and
neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain.
Objective:
This clinical study aimed to evaluate the association of leukocyte count and neutrophil-to-lymphocyte ratio with stroke severity and functional
outcome in acute ischemic stroke patients.
Methods:
This hospital-based, retrospective observational study included 112 subjects with acute ischemic stroke. All subjects had their demographic,
clinical, and laboratory data obtained. The leukocyte count and neutrophil-to-lymphocyte ratio were evaluated by stroke severity on admission and
3-month functional outcome. The severity of stroke at admission was measured using the National Institutes of Health Stroke Scale (NIHSS),
whereas the Barthel Index was used to measure 3-month functional outcome (BI). We conducted a regression analysis, adjusting for any
confounding variables.
Results:
Higher leukocyte count was significantly associated with increased risk of stroke severity (odds ratio [OR] 1.391, 95\% confidence intervals [CI],
1.121-1.725, p: 0.003) and unfavorable functional outcome (OR 1.434, 95\% CI, 1.068-1.925, p: 0.017). Higher neutrophil-to-lymphocyte ratio was
not significantly associated with increased risk of stroke severity (OR 1.181, 95\% CI, 0.947-1.474, p: 0.140) and unfavorable functional outcome
(OR 1.246, 95\% CI, 0.905-1.716, p: 0.177).
Conclusion:
Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome},
             url = {https://katalog.ukdw.ac.id/9319/},
        keywords = {Ischemic stroke, Inflammation, Leukocyte count, Neutrophil-to-lymphocyte ratio, Prognosis, Stroke}
}