%X Introduction: Testicular torsion is one of the differential diagnoses of acute scrotal and is a urological emergency. When torsion occurs, the testicles experience
ischemia, if blood flow is not restored, the damage will be irreversible starting from 4 hours and complete damage will occur at 8 hours to 12 hours after torsion.
Methods: The samples in this study were 30 male Wistar rats aged 14-18 weeks with an average weight of 180 gm-230 gm, involving 2 large groups consisting of
one control group and four intervention groups.
Results: In the treatment group given both Mannitol and Methylprednisolone (group X1), there were significant decrease in MDA and Caspase-3 expression and
significant increase in neutrophil adhesion. There was no significant different between group given Mannitol and/or Methylprednisolone and group underwent
torsion-detorsion. Group X1 also showed the best results compared to other treatment groups regarding spermatogenesis and number of seminiferous tubular
cell layer.
Discussion: The osmotic properties of Mannitol provide a protective effect against I/R injury by restoring microvascular circulation in the early phase of the I/R
injury period. Methylprednisolone can reduce neutrophil migration which in turn can reduce ROS and ultimately reduce apoptosis in germ cells.
Conclusion: Antioxidant-antioxidant combinations are more effective than the use of a single antioxidant to reduce the occurrence of apoptosis and prevent
reperfusion ischemic injury
%A Leonardo Cahyo Nugroho
%J International Journal of Pediatric Surgery
%T PROTECTIVE ROLE EFFECT OF MANNITOL AND 
METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT
%V 4
%K Methylprednisolone; Mannitol; Torsion-detorsion; Diagnosis; Surgical intervention
%D 2023
%L katalog9177
%I medtextpublications.com