relation: https://katalog.ukdw.ac.id/9177/
title: PROTECTIVE ROLE EFFECT OF MANNITOL AND   METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT
creator: Leonardo Cahyo Nugroho
subject: QL Zoologi / Ilmu Hewan
description: Introduction: Testicular torsion is one of the differential diagnoses of acute scrotal and is a urological emergency. When torsion occurs, the testicles experience  ischemia, if blood flow is not restored, the damage will be irreversible starting from 4 hours and complete damage will occur at 8 hours to 12 hours after torsion.  Methods: The samples in this study were 30 male Wistar rats aged 14-18 weeks with an average weight of 180 gm-230 gm, involving 2 large groups consisting of  one control group and four intervention groups.  Results: In the treatment group given both Mannitol and Methylprednisolone (group X1), there were significant decrease in MDA and Caspase-3 expression and  significant increase in neutrophil adhesion. There was no significant different between group given Mannitol and/or Methylprednisolone and group underwent  torsion-detorsion. Group X1 also showed the best results compared to other treatment groups regarding spermatogenesis and number of seminiferous tubular  cell layer.  Discussion: The osmotic properties of Mannitol provide a protective effect against I/R injury by restoring microvascular circulation in the early phase of the I/R  injury period. Methylprednisolone can reduce neutrophil migration which in turn can reduce ROS and ultimately reduce apoptosis in germ cells.  Conclusion: Antioxidant-antioxidant combinations are more effective than the use of a single antioxidant to reduce the occurrence of apoptosis and prevent  reperfusion ischemic injury
publisher: medtextpublications.com
date: 2023-02
type: Article
type: PeerReviewed
format: text
language: en
identifier: https://katalog.ukdw.ac.id/9177/1/Protective%20Role%20Effect%20of%20Mannitol%20and%20Methylprednisolone.pdf
identifier:   Leonardo Cahyo Nugroho  (2023) PROTECTIVE ROLE EFFECT OF MANNITOL AND METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT.  International Journal of Pediatric Surgery, 4.   ISSN 2766-5577     
relation: https://www.medtextpublications.com/open-access/protective-role-effect-of-mannitol-and-methylprednisolone-on-testicular-injury-1300.pdf