eprintid: 9143
rev_number: 10
eprint_status: archive
userid: 2098
dir: disk0/00/00/91/43
datestamp: 2024-09-12 05:16:16
lastmod: 2024-09-12 05:16:16
status_changed: 2024-09-12 05:16:16
type: article
metadata_visibility: show
contact_email: repository@staff.ukdw.ac.id
creators_name: , Rizaldy Taslim Pinzon
creators_id: 0517057601
title: THE ROLE OF HOMOCYSTEINE LEVELS AS A RISK FACTOR OF ISCHEMIC STROKE EVENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
ispublished: pub
subjects: RC0321
divisions: fak_kedokteran
full_text_status: public
keywords: homocysteine, ischemic stroke, risk factor, systematic review, meta-analysis
abstract: Introduction: Among numerous risk factors, homocysteine (Hcy) has been linked to cerebral infarction; however, results have been inconsistent. This review aimed to conduct a meta-analysis of published studies to investigate the relationship between plasma Hcy levels and the risk of ischemic stroke. Methods: A systematic literature search was conducted until November 2022 to obtain articles reporting Hcy levels in ischemic stroke patients. Review Manager software was used to perform all statistical analyses (version 5.3). Results: Initial investigation yielded 283 articles. The final evaluation included 21 articles, including two prospective studies, one retrospective cohort, and 18 case-control studies. These studies included 9888 participants, of which 5031 were admitted patients with ischemic stroke. An integrated analysis revealed that ischemic stroke patients had significantly higher levels of Hcy than controls (mean difference (MD) = +3.70, 95% confidence interval (CI) = 2.42-5.81, p < 0.001). Conclusion: This meta-analysis and systematic review indicate that ischemic stroke patients have significantly higher homocysteine levels than controls. Detecting hyperhomocysteinemia and reducing homocysteine levels should be explored among individuals at increased risk for ischemic stroke.
date: 2023-05
publication: Frontiers in Neurology
volume: 10
publisher: Frontiers Media S.A.
pagerange: 1-10
id_number: doi:10.3389/fneur.2023.1144584
refereed: TRUE
issn: 1664-2295
official_url: https://doi.org/10.3389/fneur.2023.1144584
funders: drpinzon17@gmail.com
citation:   Rizaldy Taslim Pinzon  (2023) THE ROLE OF HOMOCYSTEINE LEVELS AS A RISK FACTOR OF ISCHEMIC STROKE EVENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS.  Frontiers in Neurology, 10.  pp. 1-10.  ISSN 1664-2295     
document_url: https://katalog.ukdw.ac.id/9143/1/The%20Role%20of%20Homocysteine%20Levels%20Risk%20Factor%20of%20Ischemic%20Stroke.pdf