eprintid: 9131
rev_number: 10
eprint_status: archive
userid: 2098
dir: disk0/00/00/91/31
datestamp: 2024-09-11 06:53:52
lastmod: 2024-09-11 06:53:52
status_changed: 2024-09-11 06:53:52
type: article
metadata_visibility: show
contact_email: repository@staff.ukdw.ac.id
creators_name: , Leonardo Cahyo Nugroho
creators_name: , Afif Iman Hidayat
creators_name: , Adityas Mahendra Putra
title: PROTECTIVE ROLE EFFECT OF MANNITOL AND METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT
ispublished: pub
subjects: RD
divisions: fak_kedokteran
full_text_status: public
keywords: Methylprednisolone; Mannitol; Torsion-detorsion; Diagnosis; Surgical intervention
abstract: Introduction: Testicular torsion is one of the differential diagnoses of acute scrotal and is a urological emergency. When torsion occurs, the testicles experience ischemia, if blood flow is not restored, the damage will be irreversible starting from 4 hours and complete damage will occur at 8 hours to 12 hours after torsion. Methods: The samples in this study were 30 male Wistar rats aged 14-18 weeks with an average weight of 180 gm-230 gm, involving 2 large groups consisting of one control group and four intervention groups. Results: In the treatment group given both Mannitol and Methylprednisolone (group X1), there were significant decrease in MDA and Caspase-3 expression and significant increase in neutrophil adhesion. There was no significant different between group given Mannitol and/or Methylprednisolone and group underwent torsion-detorsion. Group X1 also showed the best results compared to other treatment groups regarding spermatogenesis and number of seminiferous tubular cell layer. Discussion: The osmotic properties of Mannitol provide a protective effect against I/R injury by restoring microvascular circulation in the early phase of the I/R injury period. Methylprednisolone can reduce neutrophil migration which in turn can reduce ROS and ultimately reduce apoptosis in germ cells.
Conclusion: Antioxidant-antioxidant combinations are more effective than the use of a single antioxidant to reduce the occurrence of apoptosis and prevent
reperfusion ischemic injury.
date: 2023-02
publication: International Journal of Pediatric Surgery
volume: 4
publisher: medtextpublications.com
pagerange: 4-9
refereed: TRUE
issn: 2766-5577
official_url: https://www.medtextpublications.com/international-journal-of-pediatric-surgery-home.php
funders: leonardocahyo@gmail.com
citation:   Leonardo Cahyo Nugroho and Afif Iman Hidayat and Adityas Mahendra Putra  (2023) PROTECTIVE ROLE EFFECT OF MANNITOL AND METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT.  International Journal of Pediatric Surgery, 4.  pp. 4-9.  ISSN 2766-5577     
document_url: https://katalog.ukdw.ac.id/9131/1/Protective%20Role%20Effect%20of%20Mannitol%20and%20Methylprednisolone.pdf