<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "PROTECTIVE ROLE EFFECT OF MANNITOL AND METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT"^^ . "Introduction: Testicular torsion is one of the differential diagnoses of acute scrotal and is a urological emergency. When torsion occurs, the testicles experience ischemia, if blood flow is not restored, the damage will be irreversible starting from 4 hours and complete damage will occur at 8 hours to 12 hours after torsion. Methods: The samples in this study were 30 male Wistar rats aged 14-18 weeks with an average weight of 180 gm-230 gm, involving 2 large groups consisting of one control group and four intervention groups. Results: In the treatment group given both Mannitol and Methylprednisolone (group X1), there were significant decrease in MDA and Caspase-3 expression and significant increase in neutrophil adhesion. There was no significant different between group given Mannitol and/or Methylprednisolone and group underwent torsion-detorsion. Group X1 also showed the best results compared to other treatment groups regarding spermatogenesis and number of seminiferous tubular cell layer. Discussion: The osmotic properties of Mannitol provide a protective effect against I/R injury by restoring microvascular circulation in the early phase of the I/R injury period. Methylprednisolone can reduce neutrophil migration which in turn can reduce ROS and ultimately reduce apoptosis in germ cells.\r\nConclusion: Antioxidant-antioxidant combinations are more effective than the use of a single antioxidant to reduce the occurrence of apoptosis and prevent\r\nreperfusion ischemic injury."^^ . "2023-02" . . "4" . . "medtextpublications.com"^^ . . . "International Journal of Pediatric Surgery"^^ . . . "27665577" . . . . . . . . . . . . . "Afif Iman Hidayat"^^ . ""^^ . "Afif Iman Hidayat "^^ . . "Adityas Mahendra Putra"^^ . ""^^ . "Adityas Mahendra Putra "^^ . . "Leonardo Cahyo Nugroho"^^ . ""^^ . "Leonardo Cahyo Nugroho "^^ . . . . . . "PROTECTIVE ROLE EFFECT OF MANNITOL AND METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT (Text)"^^ . . . . . "Protective Role Effect of Mannitol and Methylprednisolone.pdf"^^ . . . "PROTECTIVE ROLE EFFECT OF MANNITOL AND METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #9131 \n\nPROTECTIVE ROLE EFFECT OF MANNITOL AND METHYLPREDNISOLONE ON TESTICULAR INJURY POST TORSION-DETORSION IN RAT\n\n" . "text/html" . . . "RD Pembedahan"@id . .